PUBLICATIONS

KEY PUBLICATIONS

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s Disease

Rajani RM, Ellingford R, Hellmuth M, Harris SS, Taso OS, Graykowski D, Lam FKW, Arber C, Fertan E, Danial JSH, Swire M, Lloyd M, Giovannucci TA, Bourdenx M, Klenerman D, Vassar R, Wray S, Sala Frigerio C, Busche MA

PLOS Biology (2024)

Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s Disease

Harris SS, Wolf F, De Strooper B, Busche MA

Neuron (2020)

Tau suppresses neuronal activity in vivo, even before tangles form

Busche MA

Brain (2019)

Tau impairs neural circuits, dominating amyloid-ß effects, in Alzheimer models in vivo

Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT

Nature Neuroscience (2019)

Decreased amyloid-beta and increased neuronal hyperactivity by immunotherapy in Alzheimer’s models

Busche MA, Grienberger C, Keskin AD, Song B, Neumann U, Staufenbiel M, Förstl H & Konnerth A

Nature Neuroscience (2015)

Rescue of long-range circuit dysfunction in Alzheimer’s disease models

Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I & Konnerth A

Nature Neuroscience (2015)

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer’s disease

Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A & Garaschuk O

Science (2008)  |  PDF download

The β-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice

Ong-Pålsson E, Njavro JR, Wilson Y, Pigoni M, Schmidt A, Müller SA, Meyer M, Hartmann J, Busche MA, Gunnersen JM, Munro KM, Lichtenthaler SF

Mol Neurobiol (2021)

The Reciprocal Interaction Between Sleep and Alzheimer’s Disease

Harris SS, Schwerd-Kleine T, Lee BI, Busche MA

Adv Exp Med Biol (2021)

Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo

Mensch M, Dunot J, Yishan SM, Harris SS, Blistein A, Avdiu A, Pousinha PA, Giudici C, Busche MA, Jedlicka P, Willem M, Marie H

Alzheimers Res Ther (2021)

Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

Maestú F, de Haan W, Busche MA, DeFelipe J

Ageing Res Rev (2021)

Synergy between amyloid-β and tau in Alzheimer’s disease

Busche MA & Hyman BT

Nature Neuroscience (2020)

Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

Maestú F, de Haan W, Busche MA, DeFelipe J

Ageing Res Rev (2021)

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

Pigoni M, Hsia H, Hartmann J, Njavro JR, Shmueli MD, Müller SA, Güner G, Tüshaus J, Kuhn P, Kumar R, Gao P, Tran ML, Ramazanov B, Blank B, Hipgrave Ederveen AL, Von Blume J, Mulle C, Gunnersen JM, Wuhrer M, Rammes G, Busche MA, Koeglsperger T, Lichtenthaler SF

EMBO Journal (2020)

What happens with the circuit in Alzheimer’s disease in mice and humans?

Zott B, Busche MA, Sperling RA & Konnerth A

Annual Review of Neuroscience (2018)

BACE Inhibition-dependent repair of Alzheimer’s pathophysiology

Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A & Busche MA

Proceedings of the National Academy of Sciences (2017)

Impairments of neural circuit function in Alzheimer’s disease

Busche MA & Konnerth A

Philosophical Transactions of the Royal Society B (2016)

η-secretase processing of APP inhibits neuronal activity in the hippocampus

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H & Haass C

Nature (2015)

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease

Busche MA, Chen X, Henning HA, Reichwald J, Staufenbiel M, Sakmann B & Konnerth A.

Proceedings of the National Academy of Sciences (2012)